The World Science Festival Brisbane will host the Queensland premiere of A Live Presentation of 2001: A Space Odyssey, Stanley Kubrick's classic film digitally remastered and complete with live orchestra and choir.

Known as one of the most epic works in cinema's history, the film will be accompanied by the Queensland Symphony Orchestra and Australian Voices, which will be led by internationally renowned conductor Marc Taddei.

Queensland Museum CEO and Director Professor Suzanne Miller said tickets were now on sale for the signature event which will officially open the festival on Wednesday 22 March.

"We are thrilled to be able to host the Queensland premiere of such an amazing production and I could not think of a more fitting way to open the 2017 World Science Festival Brisbane," she said.

"While making the film, 2001: A Space Odyssey director Stanley Kubrick created a primarily non-verbal experience to allow the musical score to evoke an emotional response from the audience.

"He more than achieved this in the movie, but to experience this magnificent film complete with live orchestra and choir is a whole different experience."

As well as opening the festival on Wednesday March 22, there will be two additional performances on Thursday 23 March including a matinee.

The film, which is a beautiful blend of science and art deals with a range of themes from existentialism, human evolution, technology, artificial intelligence and extra-terrestrial life and features a rich soundtrack featuring classics such as Gayane Ballet Suite, The Blue Danube and Also sprach Zarathustra.

Queensland Symphony Orchestra's Chief Executive David Pratt said QSO was excited to be performing the evocative soundtrack to this iconic screen classic.

"This eclectic score features classical works from the 1800s made popular again thanks to 2001: A Space Odyssey, as well as modern compositions that pushed the boundaries of sound when the film was released in 1968,"Mr Pratt said.

"From the lush romantic crescendos of Johann Strauss' best known waltz The Blue Danube to the booming, monumental soundscape of Also sprach Zarathustra that has come to typify space exploration and the greatest achievements of humankind, this expressive soundtrack is vital to the meaning of the movie.

"Hearing a full orchestra perform is a truly captivating experience and we look forward to sharing the power of live classical music with a new audience."

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